Comparison

FRAX1036

Item no. CS-5585-50mg
Manufacturer ChemScene
Amount 50mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 1432908-05-8
Available
CAS
1432908-05-8
Purity
>98%
Formula
C28H32ClN7O
MWt
518.05
Solubility
DMSO : 5.3 mg/mL (10.23 mM; Need warming)
Clinical Information
No Development Reported
Pathway
Cytoskeleton; Cell Cycle/DNA Damage
Target
PAK; PAK
Biological Activity
FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 uM for PAK1, PAK2 and PAK4, respectively. IC50 & Target: Ki: 23.3 nM (PAK1), 72.4 nM (PAK2), 2.4 uM (PAK4)[1] In Vitro: FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 uM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 uM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells[1]. FRAX1036 (10 uM) affects the proliferation of non-small cell lung cancer (NSCLC) cells when added to KRAS prenylation inhibitors[2].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50mg
Available: In stock
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