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Bexagliflozin

Bexagliflozin

Item no.	CS-5702-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1118567-05-7
Available
Alternative Names	EGT1442; EGT0001442; THR-1442
CAS	1118567-05-7
Purity	>98%
Formula	C24H29ClO7
MWt	464.94
Solubility	DMSO : >= 100 mg/mL (215.08 mM)
Clinical Information	Phase 3
Pathway	Membrane Transporter/Ion Channel
Target	SGLT
Biological Activity	Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 uM /2 nM in SGLT1 /SGLT2 respectively. target: SGLT2 IC50: 5.6 uM (SGLT1)/ 2 nM (SGLT2) 1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively. 2) EGT1442 significantly prolonged the median survival of SHRSP rats. 3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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