F16

36098-33-6

C16H15IN2

DMSO : >= 31 mg/mL (85.59 mM)

Others

F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines. 2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones. 3, F16 caused apoptosis in A6 cells. 4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase. 5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.