AZ876

Item no.	CS-5724-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	898800-26-5
Available
CAS	898800-26-5
Purity	>98%
Formula	C24H29N3O3S
MWt	439.57
Solubility	DMSO : >= 2.6 mg/mL (5.91 mM)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	LXR
Biological Activity	AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRalpha and hLXRbeta respectively. (1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor beta (TGFbeta)-Smad2/3 signalling. (2) AZ876 prevented TGFbeta- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, alpha-smooth muscle actin. (3) The reference for administration is 20 umol/kg/day in vivo.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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