FCCP

370-86-5

C10H5F3N4O

DMSO : >= 100 mg/mL (393.44 mM); Ethanol : >= 33.3 mg/mL (131.01 mM)

Metabolic Enzyme/Protease

FCCP is a mitochondrial uncoupling agent, used in cancer research. In Vitro: FCCP (5 uM) results in a concentration-dependent decrease in Abeta and APPsbeta production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability. FCCP (5 uM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells^[1]. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation^[2].