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Olodanrigan

Olodanrigan

Item no.	CS-5781-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1316755-16-4
Similar products	1316755-16-4
Available
Alternative Names	EMA401; PD-126055
CAS	1316755-16-4
Purity	>98%
MWt	507.58
Formula	C32H29NO5
Solubility	DMSO : >= 34 mg/mL (66.98 mM); H2O : 0.1 mg/mL (0.20 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	GPCR/G Protein
Target	Angiotensin Receptor
Biological Activity	Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons^[1]^[2]^[3]^[4]. In Vivo: EMA401 (10?mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI)^[4].
Research Area	Neurological Disease; Endocrinology

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