Comparison

SRI-011381 (hydrochloride)

Item no. CS-5826-50mg
Manufacturer ChemScene
Amount 50mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Available
Purity
>98%
Formula
C20H32ClN3O
MWt
365.94
Solubility
DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic)
Clinical Information
No Development Reported
Pathway
Stem Cell/Wnt; TGF-beta/Smad
Target
TGF-beta/Smad; TGF-beta/Smad
Biological Activity
SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect[1]. IC50 & Target: TGF-beta[1] In Vitro: SRI-011381 hydrochloride promotes fibrillar Abeta clearance by macrophages, as demonstrated by the dose-dependent decreases of Abeta in the conditioned medium derived from compound-treated macrophages[1].
SRI-011381 hydrochloride (10 uM) eliminates Saikosaponin A (SSA, 30 uM)-induced protective effects on fibroblasts[2].
In Vivo: SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration[1].
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin[1].
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-beta signaling in SBE-luciferase bioluminescent reporter mice[1].
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%[1].
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50mg
Available: In stock
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