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Endoxifen (E-isomer)

Endoxifen (E-isomer)

Item no.	CS-5913-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	114828-90-9
Available
Alternative Names	E-Endoxifen
CAS	114828-90-9
Purity	>98%
Formula	C25H27NO2
MWt	373.49
Solubility	DMSO : >= 32 mg/mL (85.68 mM)
Clinical Information	No Development Reported
Pathway	Others
Target	Estrogen Receptor/ERR
Biological Activity	Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. (Z)-Endoxifen, an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen. In Vitro: Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumed that (E)-Endoxifen, structurally related to (E)-4-OH-tamoxifen, have similar pharmacological properties. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions. (E)-Endoxifen is identified as the primary degradant^[1].

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