Namodenoson

163042-96-4

C18H18ClIN6O4

DMSO : >= 31 mg/mL (56.91 mM)

GPCR/G Protein

Namodenoson (CF-102) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. IC50 & Target: Ki:0.33 nM (A3 adenosine receptor)^[1][2]. In Vitro: In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Namodenoson (2-Cl-IB-MECA) directly cause influx of Ca2+^[2]. In Vivo: Intravenous administration of 200 ug/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lasting hypotension, which was accompanied by a 50-100-fold increase in plasma histamine concentrations. Administration of a second dose of Namodenoson (2-Cl-IB-MECA) did not elicit any hemodynamic effects^[1].