alpha-Cyperone

473-08-5

C15H22O

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Others

alpha-Cyperone (alpha-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD. In Vitro: The anti-inflammatory activity of alpha-Cyperone (alpha-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFkappaB pathway in LPS-stimulated RAW 264.7 cells^[1].
alpha-Cyperone (alpha-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter^[2].