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MK-1064

MK-1064

Item no.	CS-5968-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1207253-08-4
Available
CAS	1207253-08-4
Purity	>98%
Formula	C24H20ClN5O3
MWt	461.90
Solubility	DMSO : 50 mg/mL (108.25 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	Phase 1
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Orexin Receptor (OX Receptor); Orexin Receptor (OX Receptor)
Biological Activity	MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia. target: 2-SORA [1] In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg. [2]

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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