Phenylephrine

59-42-7

167.21

H2O : 5 mg/mL (29.90 mM; Need ultrasonic)

GPCR/G Protein; Neuronal Signaling

(R)-(-)-Phenylephrine is a selective alpha₁-adrenoceptor agonist primarily used as a decongestant. In Vitro: (R)-(-)-Phenylephrine is a selective alpha₁-adrenoceptor agonist with pK_i values of 5.86, 4.87 and 4.70 for alpha_1D, alpha_1B and alpha_1A receptors respectively^[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(²⁺)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis^[3]. In Vivo: Perfusion of hearts with 100 uM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. alpha₁-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes^[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema^[5].