Comparison

NCB-0846

Item no. CS-6441-5mg
Manufacturer ChemScene
Amount 5mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 1792999-26-8
Available
CAS
1792999-26-8
Purity
>98%
Formula
C21H21N5O2
MWt
375.42
Solubility
DMSO : >= 30 mg/mL (79.91 mM)
Clinical Information
No Development Reported
Pathway
Stem Cell/Wnt; MAPK/ERK Pathway
Target
Wnt; MAP4K
Biological Activity
NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21?nM. IC50 & Target: IC50: 21?nM (TNIK)[1] In Vitro: NCB-0846 has anti-Wnt activity. NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 shows inhibitory activity against TNIK with an IC50 of 21?nM. NCB-0846 also inhibits FLT3, JAK3, PDGFRalpha, TRKA, CDK2/CycA2, and HGK. NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK within a concentration range of 0.1-0.3?uM and completely inhibits the phosphorylation of TCF4 at a concentration of 3?uM. NCB-0846 inhibits HCT116 cell growth and shows much higher (-20-fold) inhibitory activity against colony formation by the same cells in soft agar[1]. In Vivo: NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5mg
Available: In stock
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