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HJC0350

HJC0350

Item no.	CS-6510-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	885434-70-8
Available
CAS	885434-70-8
Purity	>98%
Formula	C15H19NO2S
MWt	277.38
Solubility	DMSO : 33.33 mg/mL (120.16 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	HJC0350 is a potent and specific EPAC2 antagonist with an IC₅₀ of 0.3 uM. IC50 & Target: IC50: 0.3 uM (EPAC2)^[1] In Vitro: HJC0350 has an apparent IC₅₀ value of 0.3 uM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 uM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 uM HJC0350 fully blocks the 007-AM induced decrease of FRET^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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