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LTURM34

LTURM34

Item no.	CS-6551-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1879887-96-3
Available
CAS	1879887-96-3
Purity	>98%
Formula	C24H18N2O3S
MWt	414.48
Solubility	DMSO : >= 37.5 mg/mL (90.47 mM)
Clinical Information	No Development Reported
Pathway	PI3K/Akt/mTOR; Cell Cycle/DNA Damage
Target	DNA-PK; DNA-PK
Biological Activity	LTURM34 is a specific DNA-PK inhibitor with an IC₅₀ of 0.034 uM. IC50 & Target: IC50: 0.034 uM (DNA-PK)^[1] In Vitro: LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC₅₀s are 5.8 and 8.5 uM for PI3K beta and delta, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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