Miquelianin

22688-79-5

C21H18O13

DMSO : >= 30 mg/mL (62.71 mM)

Others

Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. In Vitro: Miquelianin shows an antioxidant effect in human plasma. At 50 uM, miquelianin suppresses the consumption of the three antioxidants lycopene, beta-carotene and alpha-tocopherol significantly^[1]. In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine^[2]. Miquelianin significantly reduces the generation of beta-amyloid (Abeta) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Abeta1–40 and Abeta1–42 that is necessary for the formation of neurotoxic oligomeric Abeta species^[3]. Treatment with 0.1 uM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction, and inhibits the binding of [³H]-NA to b2-AR. Miquelianin may function to suppress invasion of breast cancer cells by controlling b2-adrenergic signaling, and may be a dietary chemopreventive factor for stress-related breast cancer^[4]. In Vivo: Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation^[3]. A flavonoid fraction obtained from a crude extract of Hypericum perforatum (St. John's wort) is remarkably active in the forced swimming test. Miquelianin is one of the compound separated from the fraction^[5].