DM4

Item no.	CS-6866-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	796073-69-3
Available
CAS	796073-69-3
Purity	>98%
Formula	C38H54ClN3O10S
MWt	780.37
Solubility	DMSO : 100 mg/mL (128.14 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Target	Microtubule/Tubulin; Microtubule/Tubulin
Biological Activity	DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. In Vitro: DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death^[1].

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