Hexa-D-arginine

673202-67-0

C36H75N25O6

H2O

Others

Hexa-D-arginine is an inhibitor of furin. In Vitro: Hexa-D-arginine (10 uM) protects against the cytotoxic effects of anthrax toxin in RAW 264.7 cells. The concentrations of Hexa-D-arginine requires to block the cleavage of PA are similar to those required to inhibit toxicity^[2]. In Vivo: Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha^[1]. Rats treated with the combination of anthrax toxins and Hexa-D-arginine exhibit a 40% survival rate at 5 h compared with a control group treated solely with anthrax toxin (0% survival rate). Administration of Hexa-D-arginine (1 mg/100 uL) also results in a considerable delay in the onset of anthrax toxemia compared with results of the control group treated solely with anthrax toxin^[2].