E3 ligase Ligand 2

5054-59-1

C13H10N2O5

DMSO : >= 36.5 mg/mL (133.10 mM)

PROTAC

E3 ligase Ligand 2 is a ligand for E3 ligase used in PROTAC technology. IC50 & Target: Ligand for E3 Ligase^[1] In Vitro: Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells^[1].