Comparison

DL-Borneol

Item no. CS-7912-5g
Manufacturer ChemScene
Amount 5g
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 507-70-0
Available
Alternative Names
(+/-)-Borneol
CAS
507-70-0
Purity
>98%
Formula
C10H18O
MWt
154.25
Solubility
DMSO : >= 100 mg/mL (648.30 mM); H2O : < 0.1 mg/mL (insoluble)
Clinical Information
No Development Reported
Pathway
Neuronal Signaling; Membrane Transporter/Ion Channel
Target
GABA Receptor; GABA Receptor
Biological Activity
DL-Borneol is a racemic mixture of D-Borneol and L-Borneol. DL-Borneol is widely used for the treatment of cardiovascular and cerebrovascular diseases in China. In Vitro: DL-Borneol increases intracellular accumulation of Rho123, and enhances P-gp substrates across the BBB in vitro, and also depresses mdr1a mRNA and P-gp expression. Furthermore, DL-Borneol could activate NF-kappaB and inhibition of NF-kappaB with MG132 and SN50 obscures the P-gp decreases induced by DL-Borneol. 10 ug/mL and 20 ug/mL DL-Borneol significantly increase phosphorylation of IkappaB expression at 30 min after treatment transiently. DL-Borneol treatment decreases P-gp expression in BMECs[1]. In Vivo: DL-Borneol significantly suppresses the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling are ameliorated in DL-Borneol-treated animals which is indicated by decreased LPO and increased SOD, GSH, CAT levels. The distinct neuronal damage observed in the kindled group is counteracted by DL-Borneol. Furthermore, it decreases the levels of GFAP which is manifested by reduced immunostaining[2]. The pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of DL-Borneol and that there are some components in Xingnaojing inhibiting the absorption of DL-Borneol[3].

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Amount: 5g
Available: In stock
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