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IRAK4-IN-1

IRAK4-IN-1

Item no.	CS-7925-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1820787-94-7
Available
CAS	1820787-94-7
Purity	>98%
Formula	C19H23N5O
MWt	337.42
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : 14.29 mg/mL (42.35 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Target	IRAK; IRAK
Biological Activity	IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC₅₀ of 7 nM. IC50 & Target: IC50: 7 nM (IRAK4)^[1] In Vitro: The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC₅₀ of 2300 nM for the rat whole blood (RWB) ^[1]. In Vivo: Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mg

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Delivery expected until 9/4/2025

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