MAK683

Item no.	CS-8054-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1951408-58-4
Similar products	1951408-58-4
Available
CAS	1951408-58-4
Purity	>98%
MWt	376.39
Formula	C20H17FN6O
Solubility	DMSO : 52 mg/mL (138.15 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	Phase 2
Pathway	Epigenetics
Target	Histone Methyltransferase
Biological Activity	MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC₅₀s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay^[1]^[2]. IC50 & Target: IC50: 59 nM (EED Alphascreen), 89 nM (LC-MS), 26 nM (ELISA)^[1] In Vitro: MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 after 14 days of treatment with an IC₅₀ of 30 nM^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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