Tradipitant

622370-35-8

C28H16ClF6N5O

10 mM in DMSO

Neuronal Signaling; GPCR/G Protein

Tradipitant is a neurokinin-1 (NK-1) antagonist. IC50 & Target: NK-1^[1] In Vitro: Results reveal that Tradipitant ([³H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal)^[1]. In Vivo: Autoradiography experiments reveal that intravenously administered Tradipitant ([³H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands^[1].