Tyrphostin AG 879

148741-30-4

C18H24N2OS

DMSO : >= 30 mg/mL (94.80 mM)

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Protein Tyrosine Kinase/RTK; Neuronal Signaling

TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 umol/L) than EGFR (IC50 >500 umol/L). target: TrKA [1], ErbB2 [2]. IC 50: ErbB2 1 umol/L [2]. In vitro: Tyrphostin AG879 significantly inhibit the A-type potassium currents in the cultured hippocampus neurons.[2] Tyrphostin AG879 can reduce gephyrin puncta in GABAergic neurons and PSD-95 puncta in glutamatergic neurons where ErbB4 expression was low. [3] In vivo: Treatment with Tyrphostin AG879 in immunodepressed mice graft with leiomyosarcoma or promyelocytic leukemia cells result in dramatic reductions in tumor sizes. [1]