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Win 18446

Win 18446

Item no.	CS-W011810-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1477-57-2
Similar products	1477-57-2
Available
CAS	1477-57-2
Purity	>98%
MWt	366.11
Formula	C12H20Cl4N2O2
Solubility	DMSO : 10.87 mg/mL (29.69 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Aldehyde Dehydrogenase (ALDH)
Biological Activity	Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC₅₀ of 0.3 uM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes^[1]^[2]. In Vitro: WIN 18446 (1 uM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells^[2]. In Vivo: Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility^[1].
Research Area	Endocrinology

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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