X-376

Item no.	DCC-DC10547-250mg
Manufacturer	DCChemicals
CASRN	1365267-27-1
Amount	250 mg
Quantity options	100 mg 1 g 250 mg
Category	Blocking Reagents & Chemicals Molecules Immunochemistry
Type	Inhibitors
Applications	IC, Blocking
Specific against	other
Purity	>98%
Smiles	ClC1=C(C([H])=C([H])C(=C1[C@@]([H])(C([H])([H])[H])OC1C(N([H])[H])=NN=C(C=1[H])C(N([H])C1C([H])=C([H])C(=C([H])C=1[H])C(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=O)=O)Cl)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1365267-27-1
Similar products	1365267-27-1
Available
Manufacturer - Applications	X-376 is a highly selective and potent inhibitor of ALK (anaplastic lymphoma kinase) tyrosine kinase, demonstrating strong activity with an IC50 of 0.61 nM. While it primarily targets ALK, it also exhibits inhibitory effects on MET kinase, though with slightly reduced potency (IC50 = 0.69 nM). Due to its robust kinase-blocking properties, X-376 shows significant anti-tumor efficacy, making it a promising candidate for cancer research and therapeutic development.
Storage Conditions	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Molecular Weight	547, 4088
Note	For research only, not for human use.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 1/8/2026

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