IU1-47

Item no.	DCC-DC23797-250mg
Manufacturer	DCChemicals
CASRN	670270-31-2
Amount	250 mg
Quantity options	100 mg 1 g 250 mg
Category	Reagents & Chemicals Molecules Immunochemistry
Type	Inhibitors
Applications	IC
Specific against	other
Purity	>98%
Smiles	CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	670270-31-2
Available
Manufacturer - Applications	IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
Molecular Weight	330, 856

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 2/12/2026

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