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GDC-0575

GDC-0575

Item no.	DCC-DC27002-250mg
Manufacturer	DCChemicals
CASRN	1196504-54-7
Amount	250 mg
Quantity options	100 mg 1 g 250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Applications	IC
Specific against	other
Purity	>98%
Smiles	O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GDC-0575,GDC 0575,GDC0575,ARRY-575,ARRY-575,ARRY575,RG7741,RG-7741,RG 7741,AK 687476,AK-687476,AK687476
Similar products	1196504-54-7
Available
Manufacturer - Applications	GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Molecular Weight	414, 732
Chemical name	(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2, 3-b]pyridin-3-yl)cyclopropanecarboxamide hydrochloride

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 3/5/2026

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