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Lisaftoclax

Lisaftoclax

Item no.	TMO-T10483-100mg
Manufacturer	TargetMol
CASRN	2180923-05-9
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Autophagy Reagents & Chemicals Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Molecules
Specific against	other
Smiles	[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Bcl-2/Bcl-xl inhibitor 1,APG-2575
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Bcl-2 Family
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	882.42
Description	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Pathways	Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T10483-100mg-datasheet.pdf

TMO-T10483-100mg-safety-datasheet.pdf