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Phenoxybenzamine hydrochloride

Phenoxybenzamine hydrochloride

Item no.	TMO-T1158-1g
Manufacturer	TargetMol
CASRN	63-92-3
Amount	1 g
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 1 mL 200 mg 2 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	100.00%
Citations	Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15(1):1402-17.
Smiles	Cl.CC(COc1ccccc1)N(CCCl)Cc1ccccc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	NSC 37448,NCI-c01661,Phenoxybenzamine HCl
Shipping Condition	Cool pack
Available
Manufacturer - Targets	CaMK\|\|\|Adrenergic Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	340.3
Description	Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
Pathways	GPCR/G Protein\|\|\|Neuroscience

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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