L002

Item no.	TMO-T11807-5mg
Manufacturer	TargetMol
CASRN	321695-57-2
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Format	Powder
Specific against	other
Purity	0,98
Smiles	COc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	321695-57-2
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Histone Acetyltransferase\|\|\|STAT
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	321.35
Description	L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.
Pathways	Chromatin/Epigenetic\|\|\|Stem Cells\|\|\|JAK/STAT signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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