Nadolol

Item no.	TMO-T1203-500mg
Manufacturer	TargetMol
CASRN	42200-33-9
Amount	500 mg
Quantity options	25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.92%
Citations	Wheeldon NM, et al. Br J Clin Pharmacol. 1994 Aug;38(2):103-8.
Smiles	CC(C)(C)NCC(O)COc1cccc2CC(O)C(O)Cc12
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Anabet,Corgard,Solgol,SQ11725
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	309.4
Description	Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.
Pathways	GPCR/G Protein\|\|\|Neuroscience
Bioactivity	Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.
Receptor	beta-adrenergic receptor

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Amount: 500 mg

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