RV01

Item no.	TMO-T12781-5mg
Manufacturer	TargetMol
CASRN	1016897-10-1
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Format	Powder
Specific against	other
Purity	0,98
Smiles	Oc1cc(O)cc(\C=C\c2ccnc3ccccc23)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1016897-10-1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TLR\|\|\|Dehydrogenase\|\|\|MAPK\|\|\|NF-κB
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	263.29
Description	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.
Pathways	Immunology/Inflammation\|\|\|NF-κB\|\|\|MAPK\|\|\|Metabolism

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TMO-T12781-5mg-datasheet.pdf

TMO-T12781-5mg-safety-datasheet.pdf