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AY 9944

AY 9944

Item no.	TMO-T14362-5mg
Manufacturer	TargetMol
CASRN	366-93-8
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Cardiovascular Research Atherosclerosis Reagents & Chemicals Molecules
Type	Molecules
Format	Powder
Specific against	other
Purity	0,98
Smiles	Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	366-93-8
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	464.3
Description	AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3β-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
Pathways	Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T14362-5mg-datasheet.pdf

TMO-T14362-5mg-safety-datasheet.pdf