« Back
Home /
Ivabradine hydrochloride

Ivabradine hydrochloride

Item no.	TMO-T2535-5mg
Manufacturer	TargetMol
CASRN	148849-67-6
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Format	Powder
Specific against	other
Purity	0,99
Smiles	N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	S 16257-2,Ivabradine HCl
Shipping Condition	Cool pack
Available
Manufacturer - Targets	HCN Channel\|\|\|Adrenergic Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	505.05
Description	Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
Pathways	Membrane transporter/Ion channel\|\|\|GPCR/G Protein\|\|\|Neuroscience

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T2535-5mg-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 5 mg

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question