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Auraptene

Auraptene

Item no.	TMO-T4115-50mg
Manufacturer	TargetMol
CASRN	495-02-3
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 20 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.17%
Citations	Takeda, K.,Utsunomiya, H.,Kakiuchi, S.,et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.J.Oleo Sci.56(5),253-260(2007).
Smiles	CC(C)=CCCC(C)=CCOc1ccc2ccc(=O)oc2c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	7-geranyloxycoumarin
Shipping Condition	Cool pack
Available
Manufacturer - Targets	BACE\|\|\|MMP
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	298.38
Description	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.
Pathways	Neuroscience\|\|\|Proteases/Proteasome

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