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Desmethoxyyangonin

Desmethoxyyangonin

Item no.	TMO-T5S0734-50mg
Manufacturer	TargetMol
CASRN	15345-89-8
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.29%
Citations	Ma Y , Sachdeva K , Liu J , et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2004, 32(11):1317.
Smiles	COc1cc(\C=C\c2ccccc2)oc(=O)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Desmethoxy yangonin,Demethoxyyangonin,5,6-Dehydrokavain
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Monoamine Oxidase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	228.24
Description	1. Desmethoxyyangonin (5, 6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.
Pathways	Neuroscience

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