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Fraxinellone

Fraxinellone

Item no.	TMO-T6S0071-5mg
Manufacturer	TargetMol
CASRN	28808-62-0
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.35%
Citations	Xing Y, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1alpha and STAT3. Pharmacol Res. 2018 Sep;135:166-180.
Smiles	[H][C@]1(OC(=O)C2=C(C)CCC[C@@]12C)c1ccoc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	28808-62-0
Shipping Condition	Cool pack
Available
Manufacturer - Targets	STAT\|\|\|PD-1/PD-L1\|\|\|HIF/HIF Prolyl-Hydroxylase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	232.27
Description	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. 3. Fraxinellone has effect in the midgut metabolism of Mythimna separata (M. separata), via protease (especially the weak alkaline trypsin-like enzyme), carboxylesterase and glutathione S-transferase.
Pathways	Immunology/Inflammation\|\|\|Chromatin/Epigenetic\|\|\|JAK/STAT signaling\|\|\|Cell Cycle/Checkpoint\|\|\|Stem Cells\|\|\|Metabolism\|\|\|Apoptosis

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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