MSA-2

Item no.	TMO-T8798-10mg
Manufacturer	TargetMol
CASRN	129425-81-6
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Adenocarcinoma Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	98.88%
Citations	Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.
Smiles	COc1cc2cc(sc2cc1OC)C(=O)CCC(O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	129425-81-6
Shipping Condition	Cool pack
Available
Manufacturer - Targets	STING
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	294.32
Description	MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]
Pathways	Immunology/Inflammation

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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