ML 254

Item no.	TMO-T8862-1mg
Manufacturer	TargetMol
CASRN	1428630-86-7
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.94%
Citations	Zhou Y , Chun A , Gogliotti R D , et al. Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2010.
Smiles	CC1(COC1)NC(=O)c1ccc(cn1)C#Cc1cccc(F)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1428630-86-7,GluR
Shipping Condition	Cool pack
Available
Manufacturer - Targets	GluR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	310.32
Description	ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.
Pathways	Neuroscience

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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