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Methylnissolin

Methylnissolin

Item no.	TMO-TN2354-1mg
Manufacturer	TargetMol
CASRN	73340-41-7
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Reagents & Chemicals Molecules
Type	Molecules
Format	Powder
Specific against	other
Purity	0,98
Smiles	[H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1c2ccc(OC)c1OC
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	3-Hydroxy-9,10-dimethoxyptercarpan
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PDGFR\|\|\|ERK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	300.31
Description	Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.
Pathways	Angiogenesis\|\|\|Tyrosine Kinase/Adaptors\|\|\|MAPK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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