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regorafenib-monohydrate

regorafenib-monohydrate

Item no.	V0072-10mg
Manufacturer	InvivoChem LLC
CASRN	1019206-88-2
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1019206-88-2
Available
Description	InvivoChem Cat #:V0072CAS #:1019206-88-2 Purity >=98% Description: Regorafenib monohydrate (also known as BAY 73-4506 monohydrate), the hydrated form of Regorafenib, is an orally bioavailable multi-kinase inhibitor targeting kinases such as VEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. It has anticancer activity and has been approved by FDA for the treatment of liver cancer. Description: References: Int J Cancer, 2011, 129(1), 245-255. References: Related CAS: 835621-07-3 (HCl); 755037-03-7 (free base)
Molecular Weight (MW)	500.83
Formula	C??H??ClF?N?O?
CAS No.	1019206-88-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL (200.9 mM)
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 30mg/mL
Chemical Name	1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea monohydrate
Synonym	BAY-734506 monohydratel; BAY 734506; BAY734506; Regorafenib HCl. Brand name: Stivarga.
SMILES Code	O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.O

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Amount: 10mg

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