« Back
Home /
ruxolitinib-sulfate

ruxolitinib-sulfate

Manufacturer	InvivoChem LLC
Category	Food Safety Reagents & Chemicals Molecules Amino Acid Analysis
Type	Biochemicals
Specific against	other
Amount	25mg
Item no.	V0077-25mg
CASRN	1092939-16-6 (sulfate)
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0077CAS #:1092939-16-6 (sulfate)Purity >=98% Description: Ruxolitinib sulfate, the sulfate salt of ruxolitinib which is also known as Jakafi, Jakavi, INC-424, INCB-18424 or INCB-018424, is the first-in class, potent, selective, and orally bioavailable JAK1/2 (Janus-associated kinase) inhibitor with IC50 of 3.3 nM/2.8 nM in cell-free assays, it exhibits > 130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib has potential antineoplastic and immunomodulating activities. It was approved in 2011 by FDA for the treatment of intermediate or high-risk myelofibrosis. Description: References: Blood. 2010 Apr 15; 115(15):3109-17; N Engl J Med. 2012 Mar 1; 366(9):799-807; N Engl J Med. 2012 Mar 1; 366(9):787-98. References: Related CAS: 1092939-17-7 (phosphate); 941678-49-5 (free base); 941685-37-6 (S-enantiomer)
Molecular Weight (MW)	404.44
Formula	C??H??N?O?S
CAS No.	1092939-16-6 (sulfate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 50 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	2% DMSO+30% PEG 300+ddH2O: 5 mg/mL
Synonyms	INCB-018424 sulfate, INCB 018424, INCB018424; INC424, INC424, INC-424; INCB18424, INCB 18424, INCB-18424; Jakafi and Jakavi (trade name)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 25mg

available

Delivery expected until 7/4/2024