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pf-4989216

pf-4989216

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	100mg
Item no.	V0151-100mg
CASRN	1276553-09-3
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0151CAS #:1276553-09-3Purity >=98% Description: PF-4989216 is a novel, potent, orally bioactive and selective small molecule inhibitor of PI3K (phosphatidylinositol 3-kinase) with potential anticancer activity. It inhibits PI3K isoforms p110alpha, p110beta, p110gamma, p110delta, and VPS34 with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM, respectively. PF-4989216 inhibited PI3K downstream signaling and subsequently led toapoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation. Description: Description: PF-4989216 is a novel, potent, orally bioactive and selective small molecule inhibitor of PI3K (phosphatidylinositol 3-kinase) with potential anticancer activity. It inhibits PI3K isoforms p110alpha, p110beta, p110gamma, p110delta, and VPS34 with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM, respectively. PF-4989216 inhibited PI3K downstream signaling and subsequently led toapoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation. with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM References: Clin Cancer Res. 2014 Feb 1; 20(3):631-43. References: References:

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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Delivery expected until 6/6/2024