amg319

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	5mg
Item no.	V0153-5mg
CASRN	1608125-21-8
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0153CAS #:1608125-21-8Purity >=98% Description: AMG319 (also known as ACP319) is a novel, potent, selective, orally bioavailable small molecule inhibitor of PI3Kdelta (phosphoinositide-3 kinase delta) with potential anticancer activity. It was originally developed by Amgen as an anti-inflammatory agent for the treatment of autoimmune conditions such as RA-rheumatoid arthritis, but was subsequently found to be able to inhibit cancer cell proliferation and might potentially be useful for cancer treatment. It inhibits PI3Kdelta with an IC50 of 18 nM, and exhibits > 47-fold selectivity for PI3Kdelta over other PI3Ks. Description: Description: AMG319 (also known as ACP319) is a novel, potent, selective, orally bioavailable small molecule inhibitor of PI3Kdelta (phosphoinositide-3 kinase delta) with potential anticancer activity. It was originally developed by Amgen as an anti-inflammatory agent for the treatment of autoimmune conditions such as RA-rheumatoid arthritis, but was subsequently found to be able to inhibit cancer cell proliferation and might potentially be useful for cancer treatment. It inhibits PI3Kdelta with an IC50 of 18 nM, and exhibits > 47-fold selectivity for PI3Kdelta over other PI3Ks. delta PI3Kdelta with an PI3Kdelta References: Cell. 1997 Oct 17; 91(2):231-41. References:References:

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Amount: 5mg

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Delivery expected until 6/6/2024