Comparison

gsk343

Item no. V0380-50mg
Manufacturer InvivoChem LLC
CASRN 1346704-33-3
Amount 50mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 1346704-33-3
Available
Description
InvivoChem Cat #:V0380CAS #:1346704-33-3Purity >=98%

Description: GSK343 is a novel, highly potent and selective inhibitor of H3-lysine 27 (H3K27) methyltransferase EZH2 with antineoplastic activity. It inhibits EZH2 with an IC50 of 4 nM in a cell-free assay, and displays > 60 fold selectivity for EZH2 over EZH1, and other histone methyltransferases. GSK343 was found to inhibit cell proliferation in some breast and prostate cancer cells. In LNCaP cells, GSK343 suppressed cell growth with IC50 value of 2.9 uM. In human EOC cells, GSK343 notably inhibited cell invasion and induced cell apoptosis. GSK343 was also found to induce LC3-II accumulation and autophagy in A549, MDA-MB-231 and HepG2 cell.

Description:

References: ACS Med Chem Lett. 2012, 3, 1091-1096; Cell Cycle. 2013 Jul 1; 12(13):2113-9.

References:
Molecular Weight (MW)
541.69
Formula
C31H39N7O2
CAS No.
1346704-33-3
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 10 mg/mL (18.5 mM)
Water: < 1 mg/mL
Ethanol: 4 mg/mL (7.4 mM)
SMILES
O=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O
Synonyms

GSK-343; GSK 343; GSK343

Chemical Name: 1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1, 2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide.

InChi Key: ULNXAWLQFZMIHX-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9, 14-17, 19-20H, 6-7, 10-13, 18H2, 1-5H3, (H, 33, 39)(H, 35, 40)

SMILES Code: O=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50mg
Available: In stock
available

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