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PFI-1 (PF-6405761)

PFI-1 (PF-6405761)

Item no.	V0413-500mg
Manufacturer	InvivoChem LLC
CASRN	1403764-72-6
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0413CAS #:1403764-72-6Purity >=98% Description: PFI-1 (PF6405761) is a novel, highly potent and selective BET (bromodomain-containing protein) inhibitor with antineoplastic activity. It inhibits BRD4 with an IC50 of 0.22 uM in cell-free assays. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Description: References: J Med Chem. 2012 Nov 26; 55(22):9831-7; Clin Cancer Res. 2013 Apr 1; 19(7):1748-59. References:
Molecular Weight (MW)	347.39
Formula	C16H17N3O4S
CAS No.	1403764-72-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 69 mg/mL (198.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2-methoxy-N-(3-methyl-2-oxo-1, 2, 3, 4-tetrahydroquinazolin-6-yl)benzenesulfonamide InChi Key: TXZPMHLMPKIUGK-UHFFFAOYSA-N InChi Code: InChI=1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21, 22)15-6-4-3-5-14(15)23-2/h3-9, 18H, 10H2, 1-2H3, (H, 17, 20) SMILES Code: O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O
Synonyms	PFI 1; PF 6405761; PFI-1; PF-6405761; PF6405761; PFI1

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Amount: 500 mg

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Delivery expected until 9/4/2025

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