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splitomicin

splitomicin

Item no.	V0437-5mg
Manufacturer	InvivoChem LLC
CASRN	5690-03-9
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	09.03.5690
Available
Description	InvivoChem Cat #:V0437CAS #:5690-03-9Purity >=98% Description: Splitomicin (known also as Splitomycin), a lactone derived from naphthol, is a potent, cell-permeable and selective inhibitor of NAD(+)-dependent histone deacetylase (HDAC) Sir2p with potential antineoplastic activity. It inhibits Sir2p with an IC50 of 60 uM. Splitomicin was discovered for yeast sirtuins but showed rather weak inhibition on human enzymes. Description: References: Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15113-8; J Biol Chem. 2014 Sep 12; 289(37):25890-906. References:
Molecular Weight (MW)	198.22
Formula	C13H10O2
CAS No.	5690-03-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 39 mg/mL (196.0 mM)
	Water: < 1 mg/mL
	Ethanol: 39 mg/mL (196.0 mM)
Other info	Chemical Name: 1H-benzo[f]chromen-3(2H)-one InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N InChi Code: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5, 7H, 6, 8H2 SMILES Code: O=C1CCC2=C3C=CC=CC3=CC=C2O1
Synonyms	Splitomicin; Splitomycin

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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