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Splitomicin (Splitomycin)

Splitomicin (Splitomycin)

Item no.	V0437-100mg
Manufacturer	InvivoChem LLC
CASRN	5690-03-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0437CAS #:5690-03-9Purity >=98% Description: Splitomicin (known also as Splitomycin), a lactone derived from naphthol, is a potent, cell-permeable and selective inhibitor of NAD(+)-dependent histone deacetylase (HDAC) Sir2p with potential antineoplastic activity. It inhibits Sir2p with an IC50 of 60 uM. Splitomicin was discovered for yeast sirtuins but showed rather weak inhibition on human enzymes. Description: References: Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15113-8; J Biol Chem. 2014 Sep 12; 289(37):25890-906. References:
Molecular Weight (MW)	198.22
Formula	C13H10O2
CAS No.	5690-03-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 39 mg/mL (196.0 mM)
	Water: < 1 mg/mL
	Ethanol: 39 mg/mL (196.0 mM)
Other info	Chemical Name: 1H-benzo[f]chromen-3(2H)-one InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N InChi Code: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5, 7H, 6, 8H2 SMILES Code: O=C1CCC2=C3C=CC=CC3=CC=C2O1
Synonyms	Splitomicin; Splitomycin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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