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AC480 (BMS599626)

AC480 (BMS599626)

Item no.	V0554-5mg
Manufacturer	InvivoChem LLC
CASRN	714971-09-2
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 500 mg 50 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	714971-09-2
Available
Description	InvivoChem Cat #:V0554CAS #:714971-09-2Purity >=98% Description: AC480 (also known as BMS-599626) is a novel, potent, orally bioavailable, selective and efficacious inhibitor of HER1/2 (human epidermal growth factor receptors) with potential anticancer activity. It inhibits HER1/2 with IC50s of 20 nM and 30 nM, respectively. It shows ca.8-fold less potency against HER4, and is > 100-fold less active to VEGFR2, c-Kit, Lck, MET etc. Oral administration of AC480 has been demonstrated to suppress the growth of Sal2 tumor, GEO xenograft tumor, KPL-4 and BT474 breast tumors, N87 gastric tumor, A549 and L2987 non–small-cell lung tumors in nude mice. Description: References: Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):6186-93; Invest New Drugs. 2011 Aug; 29(4):554-61. References: Related CAS: 714971-09-2 (free base); 873837-23-1 (HCl salt)
Molecular Weight (MW)	530.55
Formula	C27H27FN8O3
CAS No.	714971-09-2 (free base)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 113 mg/mL (213.0 mM)
	Water: < 1 mg/mL
	Ethanol: 20 mg/mL (37.7 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	BMS-599626; BMS599626; BMS 599626; AC 480; AC-480; AC 480 hydrochloride; BMS599626 HCl; BMS599626 hydrochloride; AC480; AC 480 HCl;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 10/2/2025

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